Dynamics of Cancer
- Book Information
- Introduction
- Part I Background
- Chapter 2 Age of Cancer Incidence
- Chapter 3 Multistage Progression
- 3.1 Terminology
- 3.2 What Is Multistage Progression?
- 3.3 Multistage Progression in Colorectal Cancer
- 3.4 Alternative Pathways to Colorectal Cancer
- 3.5 Changes during Progression
- 3.6 What Physical Changes Drive Progression?
- 3.7 What Processes Change during Progression?
- 3.8 How Do Changes Accumulate in Cell Lineages?
- 3.9 Summary
- Part II Molecular Processes
- Chapter 4 History of Theories
- 4.1 Origins of Multistage Theory
- 4.2 A Way to Test Multistage Models
- 4.3 Cancer Is a Genetic Disease
- 4.4 Can Normal Somatic Mutation Rates Explain Multistage Progression?
- 4.5 Clonal Expansion of Premalignant Stages
- 4.6 The Geometry of Cell Lineages
- 4.7 Hypermutation, Chromosomal Instability, and Selection
- 4.8 Epigenetics: Methylation and Acetylation
- 4.9 Summary
- Chapter 5 Progression Dynamics
- Chapter 4 History of Theories
- Part III Individual Interactions
- Part IV Population Consequences
- Part V Studying Evolution
- Conclusions
- Appendix: Incidence
- References
- List of Figures
Copyright © 2007 Steven A. Frank
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